Description

5-Benzylaminocarbony-2'-o-Methyl-5'-o-Dmtr-Uridine is a sophisticated, chemically modified nucleoside derivative designed for advanced oligonucleotide synthesis. This compound is a critical building block in the production of antisense oligonucleotides and other therapeutic nucleic acids, where precise chemical modification is essential for stability and efficacy. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs specializing in nucleic acid therapeutics and diagnostics.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for introducing specific modifications into oligonucleotide chains.
• Antisense Oligonucleotide (ASO) Development: Used in the research and manufacturing of ASOs for targeted gene silencing therapies.
• siRNA and miRNA Synthesis: Serves as a modified monomer to enhance the nuclease resistance and pharmacokinetic properties of RNA-based therapeutics.
• Diagnostic Probe Manufacturing: Employed in the creation of labeled probes for genetic testing and molecular diagnostics.
• Academic and Industrial Research: A vital reagent for studying nucleic acid structure, function, and for developing novel therapeutic modalities.
• Process Development & Scale-Up: Supports process optimization and GMP-grade production for clinical-stage and commercial nucleic acid drugs.

Basic Information

Product Name	5-Benzylaminocarbony-2'-o-Methyl-5'-o-Dmtr-Uridine
CAS No.	1374692-38-2
Molecular Formula	C35H37N3O9
Molecular Weight	643.69 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-5-(N-benzylcarboxamido)uridine; 2'-O-Methyl-5-(N-benzylcarboxamido)uridine, 5'-O-DMTr-; 5-(N-Benzylcarbamoyl)-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine; DMTr-2'-OMe-5-BzU; 2'-O-Methyl-5-benzylaminocarbonyluridine 5'-O-DMTr ether; Modified Uridine Phosphoramidite Precursor; BzU(2'-OMe) DMTr-CE Phosphoramidite Intermediate
EINECS	Contact for details

Quality Control

Every batch of 5-Benzylaminocarbony-2'-o-Methyl-5'-o-Dmtr-Uridine is manufactured and tested under strict quality management systems. We ensure high purity and consistency suitable for sensitive pharmaceutical R&D and production applications. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccants and temperature control.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.