Description

5'-o-(4,4'-Dimethoxytrityl)-2'-o-Methyl-3'-o-Acetyl-5-Iodouridine CAS NO 1374692-34-8 is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound is a critical building block for the production of modified RNA sequences, offering precise control over structure and function. It is essential for researchers and manufacturers in the fields of therapeutic oligonucleotide development, antisense technology, and diagnostic probe manufacturing.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of 2'-O-methyl modified RNA strands.
• Antisense Oligonucleotide (ASO) Production: Used to incorporate 5-iodouridine modifications, which can be further functionalized via cross-coupling reactions for labeling or conjugation.
• siRNA and miRNA Research: Enables the site-specific introduction of modified nucleotides to enhance stability, specificity, and pharmacokinetic properties of RNAi therapeutics.
• Diagnostic Probe Development: Serves as a starting material for creating labeled probes used in fluorescence in situ hybridization (FISH) and other detection assays.
• Medicinal Chemistry & Drug Discovery: A valuable intermediate in the search for novel nucleoside-based antiviral and anticancer agents.
• Academic & Industrial R&D: Supports fundamental research in nucleic acid chemistry, structure-activity relationships, and the development of new synthetic methodologies.

Basic Information

Product Name	5'-o-(4,4'-Dimethoxytrityl)-2'-o-Methyl-3'-o-Acetyl-5-Iodouridine
CAS No.	1374692-34-8
Molecular Formula	C33H33IN2O9
Molecular Weight	752.53 g/mol
Synonyms	5-Iodo-2'-O-methyl-3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)uridine; 5-Iodo-2'-O-methyl-3'-O-acetyl-5'-O-DMT-uridine; 5-Iodo-2'-O-methyluridine-3'-acetate-5'-DMT; DMT-2'-O-Me-3'-O-Ac-5-I-Uridine; 1-[(2R,3R,4R,5R)-5-[Bis(4-methoxyphenyl)-phenylmethoxy]-4-acetoxy-3-methoxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and moisture content. Our quality management system is designed to support GMP-grade applications and ensure supply chain reliability for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.