Description

Methyl 2-[(E)-2-(Dimethylamino)Vinyl]-5-Oxo-6-(4H-1,2,4-Triazol-4-Yl)-5,6-Dihydro-1,6-Naphthyridine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and antiviral drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of clinical trial materials.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays and target validation studies.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Methyl 2-[(E)-2-(Dimethylamino)Vinyl]-5-Oxo-6-(4H-1,2,4-Triazol-4-Yl)-5,6-Dihydro-1,6-Naphthyridine
CAS No.	1374510-79-8
Molecular Formula	C16H18N6O2
Molecular Weight	326.36 g/mol
Synonyms	2-[(E)-2-(Dimethylamino)ethenyl]-5-oxo-6-(4H-1,2,4-triazol-4-yl)-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid methyl ester; Methyl 2-[(E)-2-(dimethylamino)vinyl]-5-oxo-6-(1,2,4-triazol-4-yl)-5,6-dihydro-1,6-naphthyridine-3-carboxylate; 1374510-79-8; 1,6-Naphthyridine intermediate; Triazole-naphthyridine derivative
EINECS	Contact for details

Quality Control

Our Methyl 2-[(E)-2-(Dimethylamino)Vinyl]-5-Oxo-6-(4H-1,2,4-Triazol-4-Yl)-5,6-Dihydro-1,6-Naphthyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, supporting compliance with internal and regulatory specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened only in a moisture-controlled environment.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.