Description

(8S,9R)-5-Fluoro-8-(4-Fluorophenyl)-9-(1-Methyl-1H-1,2,4-Triazol-5-Yl)-8,9-Dihydro-2H-Pyrido[4,3,2-De]Phthalazin-3(7H)-One Tosylate is a high-purity, non-racemic pharmaceutical intermediate and reference standard of significant commercial interest. Its value lies in its role as a key chiral building block for the research and development of novel, targeted therapeutic agents. This compound is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the synthesis of complex heterocyclic molecules, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of advanced active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.
• Process Chemistry Research: Serves as a model compound for optimizing asymmetric synthesis routes and scaling up production.
• Drug Discovery & Development: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Potential use as a tool compound in biochemical assays to study specific enzyme or receptor interactions.
• Custom Synthesis Starting Material: Provides a complex, fluorinated heterocyclic core for the preparation of bespoke chemical libraries.

Basic Information

Product Name	(8S,9R)-5-Fluoro-8-(4-Fluorophenyl)-9-(1-Methyl-1H-1,2,4-Triazol-5-Yl)-8,9-Dihydro-2H-Pyrido[4,3,2-De]Phthalazin-3(7H)-One Tosylate
CAS No.	1373431-65-2
Molecular Formula	C27H22F2N6O4S
Molecular Weight	564.57 g/mol
Synonyms	5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 4-methylbenzenesulfonate; (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one p-toluenesulfonate; (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt; CAS 1373431-65-2; Fluorinated Pyridophthalazinone Tosylate; Chiral Triazole-Containing Intermediate
EINECS	Contact for details

Quality Control

Our (8S,9R)-5-Fluoro-8-(4-Fluorophenyl)-9-(1-Methyl-1H-1,2,4-Triazol-5-Yl)-8,9-Dihydro-2H-Pyrido[4,3,2-De]Phthalazin-3(7H)-One Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for advanced research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and traceable to reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Chiral Purity (Chiral HPLC)	≥98.0% (de)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.