Description

Gsk2636771 CAS NO 1372540-25-4 is a potent and selective small molecule inhibitor of the protein kinase PDK1 (3-phosphoinositide-dependent protein kinase-1). This compound matters as a critical research tool for investigating the PI3K/AKT signaling pathway, which is a central regulator of cell growth, proliferation, and survival, and is frequently dysregulated in cancers. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, metabolic disease research, and the development of targeted therapeutic agents.

Application

• Biochemical Research: Used as a selective PDK1 inhibitor to study kinase signaling pathways and enzyme kinetics in vitro.
• Cell-Based Assays: Employed to investigate the role of PDK1 and the PI3K/AKT pathway in cell proliferation, apoptosis, and metabolism.
• Oncology Research: A key tool for validating PDK1 as a therapeutic target in various cancer models, including solid tumors and hematological malignancies.
• Drug Discovery & Development: Serves as a reference compound or a starting point for the design and optimization of novel PDK1 inhibitors.
• Signal Transduction Studies: Facilitates the dissection of downstream effects of PDK1 inhibition on other pathway components like AKT, SGK, and RSK.

Basic Information

Product Name	Gsk2636771
CAS No.	1372540-25-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	GSK2636771; GSK-2636771; 2-[4-[(3S)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl]-1H-indole-5-carbonitrile; PDK1 Inhibitor GSK2636771; 1H-Indole-5-carbonitrile, 2-[4-[(3S)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-
EINECS	Contact for details

Quality Control

Our Gsk2636771 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.