Description

tert-Butyl 4-Methyl-5-Oxo-3-(4-(Trifluoromethyl)Phenyl)-5,6-Dihydropyridine-1(2H)- CAS NO 1372173-59-5 is a high-purity, advanced pharmaceutical intermediate characterized by its complex dihydropyridine core and trifluoromethylphenyl substituent. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory applications.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, leveraging the physicochemical properties imparted by the trifluoromethyl group.
• API Development: Integral to the scalable production route development for new Active Pharmaceutical Ingredients (APIs) requiring a functionalized dihydropyridine scaffold.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and process development for client molecules.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, fluorinated compound synthesis, and novel reaction methodologies.

Basic Information

Product Name	tert-Butyl 4-Methyl-5-Oxo-3-(4-(Trifluoromethyl)Phenyl)-5,6-Dihydropyridine-1(2H)- CAS NO 1372173-59-5
CAS No.	1372173-59-5
Molecular Formula	C18H20F3NO2
Molecular Weight	339.36 g/mol
Synonyms	1(2H)-Pyridinecarboxylic acid, 5,6-dihydro-4-methyl-5-oxo-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester; tert-Butyl 4-methyl-5-oxo-3-[4-(trifluoromethyl)phenyl]-5,6-dihydro-1(2H)-pyridinecarboxylate; 3-(4-(Trifluoromethyl)phenyl)-4-methyl-5-oxo-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-tert-Butyl 4-methyl-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine-1-carboxylate; DHP Intermediate 1372173-59-5; Trifluoromethyl DHP Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Methyl-5-Oxo-3-(4-(Trifluoromethyl)Phenyl)-5,6-Dihydropyridine-1(2H)- CAS NO 1372173-59-5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable supply for sensitive pharmaceutical development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to moisture and should be handled under inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.