Description

4-(Trifluoroacetyl)Piperidine Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine scaffold and trifluoroacetyl functional group. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing active ingredients targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the trifluoromethyl group, a common moiety in modern drug design.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, where the fluorine atoms can improve compound efficacy and environmental profile.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme inhibition and receptor binding mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4-(Trifluoroacetyl)Piperidine Hcl
CAS No.	1372103-92-8
Molecular Formula	C7H11ClF3NO
Molecular Weight	217.62 g/mol
Synonyms	4-(Trifluoroacetyl)piperidine hydrochloride; 1-(2,2,2-Trifluoroacetyl)piperidin-4-one hydrochloride (incorrect but common); Piperidine, 4-(trifluoroacetyl)-, hydrochloride; 4-Trifluoroacetylpiperidine HCl; 4-TFAP HCl; 4-(Trifluoroacetyl)piperidine Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our 4-(Trifluoroacetyl)Piperidine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.