Description

Posaconazole is a potent, broad-spectrum triazole antifungal agent used to prevent and treat invasive fungal infections. Its efficacy against a wide range of pathogens, including Aspergillus and Candida species, makes it a critical component in modern antifungal therapy. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing formulations for immunocompromised patients in hospital and clinical settings.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of oral suspensions, delayed-release tablets, and intravenous formulations.
• Antifungal Prophylaxis: Used in drug products to prevent invasive fungal infections in high-risk patients, such as those undergoing chemotherapy or organ transplantation.
• Treatment of Refractory Infections: Key component in medications designed to treat infections that are resistant to other azole antifungals.
• Veterinary Pharmaceuticals: Potential application in developing antifungal treatments for animals.
• Research & Development: Serves as a reference standard and building block in microbiological research and the development of new antifungal agents.

Basic Information

Product Name	Posaconazole
CAS No.	1370790-85-4
Molecular Formula	C37H42F2N8O4
Molecular Weight	700.78 g/mol
Synonyms	SCH 56592; Noxafil; Posaconazol; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-{4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1,2,4-oxadiazol-3-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
EINECS	Contact for details

Quality Control

Our Posaconazole is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical actives. Quality is assured through comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with in-house specifications developed in alignment with ICH Q7 and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.