Description

5-Chloro-2-Cyclobutylpyridine is a high-purity, advanced pharmaceutical intermediate and versatile heterocyclic building block. Its unique structure, featuring a pyridine core substituted with a chloro group and a cyclobutyl ring, makes it a critical synthon for constructing complex molecules in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or components for OLEDs, due to its electron-deficient pyridine moiety.
• Chemical Biology Probe: Utilized as a core structure for designing molecular probes and tool compounds to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Chloro-2-Cyclobutylpyridine
CAS No.	1369933-64-1
Molecular Formula	C9H10ClN
Molecular Weight	167.64 g/mol
Synonyms	2-Cyclobutyl-5-chloropyridine; 5-Chloro-2-cyclobutylpyridine; Pyridine, 5-chloro-2-cyclobutyl-; 1369933-64-1
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Cyclobutylpyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7, and REACH regulations as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.