Description

Cobimetinib Fumarate CAS NO 1369665-02-0 is a high-purity, small molecule pharmaceutical active ingredient (API) and a key intermediate in advanced oncology research and drug development. This compound is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MEK), playing a critical role in the MAPK/ERK signaling pathway. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in the development of targeted cancer therapies, particularly for melanoma and other solid tumors.

Application

• Active Pharmaceutical Ingredient (API) in the commercial manufacture of targeted cancer therapeutics.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research for studying the MAPK/ERK pathway and its role in cell proliferation and survival.
• Preclinical & Clinical Development as a critical raw material for formulating drug products for oncology trials.
• Process Chemistry as a key intermediate for the synthesis of novel MEK inhibitor analogs.

Basic Information

Product Name	Cobimetinib Fumarate
CAS No.	1369665-02-0
Molecular Formula	C21H21F3INO4 • C4H4O4
Molecular Weight	659.33 g/mol
Synonyms	Cobimetinib fumarate; GDC-0973 fumarate; XL-518 fumarate; (S)-[3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone fumarate; MEK inhibitor GDC-0973; Cotellic® (brand name salt form)
EINECS	Contact for details

Quality Control

Our Cobimetinib Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) are provided with each shipment, detailing compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.