Description

(3R)-1-(Quinazolin-4-Yl)Pyrrolidin-3-Amine CAS NO 1365936-76-0 is a high-purity chiral amine building block featuring a quinazoline core. This compound is of significant value in pharmaceutical research and development, serving as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel small-molecule drug candidates.
• Kinase Inhibitor Synthesis: Used in the construction of potential kinase inhibitors, leveraging the quinazoline pharmacophore.
• Chemical Biology Probes: Serves as a building block for creating tool compounds and probes to study biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of advanced pharmaceutical intermediates.
• Asymmetric Synthesis: Utilized in chiral pool synthesis due to its defined (3R) stereochemistry.
• Academic Research: Used in university and institutional labs for exploratory medicinal chemistry projects.

Basic Information

Product Name	(3R)-1-(Quinazolin-4-Yl)Pyrrolidin-3-Amine
CAS No.	1365936-76-0
Molecular Formula	C12H14N4
Molecular Weight	214.27 g/mol
Synonyms	(R)-1-(Quinazolin-4-yl)pyrrolidin-3-amine; (3R)-1-(4-Quinazolinyl)-3-pyrrolidinamine; 1-(Quinazolin-4-yl)-D-prolinamine; 1365936-76-0; (R)-1-(Quinazolin-4-yl)pyrrolidin-3-amine; 3-Pyrrolidinamine, 1-(4-quinazolinyl)-, (3R)-; (R)-3-Amino-1-(quinazolin-4-yl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (3R)-1-(Quinazolin-4-Yl)Pyrrolidin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.