Description

(2S)-4,4-Difluoro-2-Methylpyrrolidine-2-Carboxylic Acid CAS NO 1363384-65-9 is a high-purity, chiral fluorinated pyrrolidine derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a constrained pyrrolidine scaffold and fluorine atoms, which are essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and other biologically relevant compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor drug discovery programs.
• Agrochemical Research: Used as a building block for creating novel herbicides, fungicides, and insecticides with enhanced activity and stability.
• Organofluorine Chemistry: Serves as a valuable substrate for studying fluorine introduction and its effects on molecular conformation and reactivity.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a core structure for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(2S)-4,4-Difluoro-2-Methylpyrrolidine-2-Carboxylic Acid
CAS No.	1363384-65-9
Molecular Formula	C7H11F2NO2
Molecular Weight	179.16 g/mol
Synonyms	(2S)-4,4-Difluoro-2-methylpyrrolidine-2-carboxylic acid; (2S)-2-Methyl-4,4-difluoropyrrolidine-2-carboxylic acid; 4,4-Difluoro-2-methyl-L-proline; (S)-4,4-Difluoro-2-methylpyrrolidine-2-carboxylic acid; L-4,4-Difluoro-2-methylproline; 1363384-65-9; (2S)-4,4-Difluoro-2-methyl-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (2S)-4,4-Difluoro-2-Methylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.