Description

Ethyl 1-Cbz-3-Isopropylpiperidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with orthogonal protecting groups. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile functional groups.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog in the design of peptide-based therapeutics.
• Chemical Biology Probes: Employed in the development of tool compounds and labeled ligands for target identification and validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Used in university laboratories for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 1-Cbz-3-Isopropylpiperidine-3-Carboxylate
CAS No.	1363166-26-0
Molecular Formula	C19H27NO4
Molecular Weight	333.43 g/mol
Synonyms	Ethyl 1-[(benzyloxy)carbonyl]-3-(propan-2-yl)piperidine-3-carboxylate; 1-Carbobenzoxy-3-isopropyl-3-piperidinecarboxylic Acid Ethyl Ester; 3-Isopropyl-1-(phenylmethoxy)carbonyl-3-piperidinecarboxylic Acid Ethyl Ester; 1-Cbz-3-(i-Pr)-piperidine-3-carboxylic Acid Ethyl Ester; 1-N-Cbz-3-isopropylpiperidine-3-carboxylic Acid Ethyl Ester; Ethyl 3-Isopropyl-1-(((benzyloxy)carbonyl)amino)piperidine-3-carboxylate (tautomeric form); Z-3-Isopropyl-3-piperidinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 1-Cbz-3-Isopropylpiperidine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.