Description

5-Bromo-3-(Trifluoromethoxy)Pyridin-2-Amine CAS NO 1361852-35-8 is a high-value, multi-functional pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic combination of bromine and trifluoromethoxy substituents, which are essential for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl and heteroaryl systems.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes and tags used in biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine motifs.

Basic Information

Product Name	5-Bromo-3-(Trifluoromethoxy)Pyridin-2-Amine
CAS No.	1361852-35-8
Molecular Formula	C6H4BrF3N2O
Molecular Weight	257.01 g/mol
Synonyms	2-Amino-5-bromo-3-(trifluoromethoxy)pyridine; 5-Bromo-3-(trifluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 5-bromo-3-(trifluoromethoxy)-; 1361852-35-8; 5-Bromo-3-trifluoromethoxypyridin-2-amine; 5-Bromo-3-(trifluoromethoxy)-2-aminopyridine; 2-Amino-5-bromo-3-trifluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(Trifluoromethoxy)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.