Description

3-Bromo-5-(Trifluoromethoxy)Pyridin-2-Amine is a high-value, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and trifluoromethoxy substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethoxy group.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a scaffold for medicinal chemistry and library synthesis.
• Ligand and Catalyst Development: Utilized to create novel nitrogen-containing ligands for transition metal catalysis.

Basic Information

Product Name	3-Bromo-5-(Trifluoromethoxy)Pyridin-2-Amine
CAS No.	1361693-01-7
Molecular Formula	C6H4BrF3N2O
Molecular Weight	257.01 g/mol
Synonyms	2-Amino-3-bromo-5-(trifluoromethoxy)pyridine; 3-Bromo-5-(trifluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 3-bromo-5-(trifluoromethoxy)-; 1361693-01-7; 3-Bromo-5-trifluoromethoxypyridin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-(Trifluoromethoxy)Pyridin-2-Amine is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.