Description

Methyl 6-Chloro-5-(Trifluoromethyl)Nicotinate is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated and trifluoromethylated pyridine core. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of agrochemicals and life science products where the introduction of fluorine atoms enhances metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Chemical Research & Development: Serves as a versatile substrate for cross-coupling reactions, functional group transformations, and scaffold diversification in medicinal chemistry.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring fluorinated aromatic systems.

Basic Information

Product Name	Methyl 6-Chloro-5-(Trifluoromethyl)Nicotinate
CAS No.	1360952-35-7
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 6-chloro-5-(trifluoromethyl)pyridine-3-carboxylate; 6-Chloro-5-(trifluoromethyl)nicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 6-chloro-5-(trifluoromethyl)-, methyl ester; Methyl 6-chloro-5-trifluoromethylnicotinate; 1360952-35-7
EINECS	Contact for details

Quality Control

Our production of Methyl 6-Chloro-5-(Trifluoromethyl)Nicotinate adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.