Description

2-Chloro-5-(Chloromethyl)Nicotinonitrile is a high-value, multi-functional chemical intermediate featuring a reactive chloromethyl group on a pyridine core. This compound matters for its versatility in constructing complex molecular architectures, particularly in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized pyridine motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the pyridine scaffold is essential for bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-5-(Chloromethyl)Nicotinonitrile
CAS No.	1360900-22-6
Molecular Formula	C7H4Cl2N2
Molecular Weight	187.03 g/mol
Synonyms	2-Chloro-5-(chloromethyl)pyridine-3-carbonitrile; 3-Cyano-2-chloro-5-(chloromethyl)pyridine; 5-(Chloromethyl)-2-chloronicotinonitrile; 2-Chloro-5-chloromethyl-3-cyanopyridine; 1360900-22-6; Nicotinonitrile, 2-chloro-5-(chloromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Chloromethyl)Nicotinonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive chloromethyl group, it is recommended to store under an inert atmosphere for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.