Description

Thiol-Peg3-Phosphonic Acid Ethyl Ester is a specialized bifunctional linker molecule featuring a terminal thiol group and a phosphonic acid ethyl ester moiety, connected by a triethylene glycol (PEG3) spacer. This unique structure is critical for creating stable, hydrophilic, and functionalized surfaces in advanced materials science and bioconjugation. It is essential for researchers and manufacturers in the pharmaceutical and nanotechnology sectors who require precise surface modification and controlled molecular assembly. The compound's dual reactivity enables robust anchoring to metal oxides via the phosphonate group while providing a thiol handle for coupling to biomolecules or other functional units.

Application

• Surface Functionalization: Key for modifying metal oxide surfaces (e.g., titanium, stainless steel, ITO) to create self-assembled monolayers (SAMs) for biosensors and implants.
• Bioconjugation & Drug Delivery: Acts as a heterobifunctional crosslinker for attaching peptides, proteins, or drugs to nanoparticles or solid supports, leveraging thiol-maleimide or thiol-gold chemistry.
• Nanoparticle Capping & Stabilization: Used to cap quantum dots, gold, or other metallic nanoparticles, providing colloidal stability in aqueous media through its hydrophilic PEG spacer.
• Polymer & Material Science: Serves as a chain transfer agent or functional monomer in controlled radical polymerization to introduce phosphonate groups into polymers.
• Corrosion Inhibition: Applied in formulations to create protective coatings on metal surfaces, where the phosphonate group chelates to the metal substrate.
• Diagnostic Assay Development: Utilized to functionalize microarray slides or sensor chips for immobilizing capture probes in diagnostic applications.

Basic Information

Product Name	Thiol-Peg3-Phosphonic Acid Ethyl Ester
CAS No.	1360716-43-3
Molecular Formula	C9H21O6PS
Molecular Weight	288.30 g/mol
Synonyms	3-[2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy]propylphosphonic Acid Diethyl Ester; (3-{2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy}propyl)phosphonic Acid Diethyl Ester; HS-PEG3-Phosphonic Acid Diethyl Ester; Thiol-PEG3-Phosphonate; SH-PEG3-P(O)(OEt)2; 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-aza-2-silatetradecan-14-oic Acid, 13-mercapto-, 2,2-Dimethyl-1,3-dioxolan-4-ylmethyl Ester (related protected form); Diethyl (3-{2-[2-(2-sulfanylethoxy)ethoxy]ethoxy}propyl)phosphonate (IUPAC)
EINECS	Contact for details

Quality Control

Our Thiol-Peg3-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. Standard quality control includes identity confirmation by NMR and FT-IR, purity assessment by HPLC, and verification of the thiol content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your R&D and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and maintain stability. The product is moisture-sensitive; keep the container tightly sealed in a cool, dry place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.