Description

Anlotinib CAS NO 1360460-82-7 is a potent and selective multi-targeted receptor tyrosine kinase inhibitor (TKI) used in advanced pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, which is critical for investigating novel oncology therapeutics. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on developing treatments for various solid tumors. We supply high-purity Anlotinib to support critical pre-clinical and clinical-stage drug development programs globally.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the formulation of finished oncology drug products.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Biomedical Research: A key tool compound for in vitro and in vivo studies targeting VEGFR, PDGFR, FGFR, and c-Kit signaling pathways.
• Drug Discovery & Development: Employed in high-throughput screening, pharmacokinetics (PK), pharmacodynamics (PD), and toxicology studies.
• Clinical Trial Material (CTM): Supplied under appropriate quality agreements for use in Phase I-III clinical trials.
• Generic Drug Development: Used by manufacturers developing bioequivalent versions of approved Anlotinib-based therapies.

Basic Information

Product Name	Anlotinib
CAS No.	1360460-82-7
Molecular Formula	C23H21FN4O3
Molecular Weight	420.44 g/mol
Synonyms	Anlotinib Hydrochloride; AL3818; N-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-quinolyl]-N'-methyl-N'-prop-2-ynylurea; 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-quinolyl]carbamoyl]-N-methyl-prop-2-yn-1-amine; AL-3818; Anlotinib HCl; Anlotinib (free base)
EINECS	Contact for details

Quality Control

Our Anlotinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting full compliance are provided with every shipment. We support development and commercial needs with materials suitable for GMP and non-GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.