Description

Fluzoparib CAS NO 1358715-18-0 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor, representing a significant advancement in targeted cancer therapy. Its primary value lies in its ability to induce synthetic lethality in cancer cells with homologous recombination repair deficiencies, such as those harboring BRCA mutations. This compound is essential for pharmaceutical R&D teams, clinical researchers, and manufacturers focused on developing next-generation oncology treatments, particularly for ovarian, breast, and prostate cancers.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of targeted anti-cancer drugs.
• Oncology Research: Critical reference standard and investigational compound for studying PARP inhibition mechanisms and synthetic lethality.
• Preclinical & Clinical Development: Used in pharmacokinetic, pharmacodynamic, and toxicology studies to support IND (Investigational New Drug) filings.
• Combinatorial Therapy Studies: Investigated in combination with chemotherapy, radiotherapy, and other targeted agents to enhance therapeutic efficacy.
• Biomarker Research: Tool for identifying and validating predictive biomarkers of response to PARP inhibitor therapy.

Basic Information

Product Name	Fluzoparib
CAS No.	1358715-18-0
Molecular Formula	C19H14F3N5O2
Molecular Weight	401.34 g/mol
Synonyms	SHR-3162; Fluzoparibum; (S)-2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)benzamide; PARP Inhibitor SHR-3162; SHR3162
EINECS	Contact for details

Quality Control

Our Fluzoparib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical use. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.