Description

Belizatinib CAS NO 1357920-84-3 is a potent and selective small molecule inhibitor targeting specific tyrosine kinases, representing a significant advancement in targeted therapeutic research. Its core value lies in its high specificity and potential for developing novel treatments for challenging conditions. This compound is essential for pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on oncology and precision medicine.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced investigational drug candidates.
• Oncology Research: Used as a reference standard and active agent in preclinical studies targeting specific kinase pathways involved in cancer proliferation.
• Biochemical Assay Development: Employed as a tool compound to validate assays, study enzyme kinetics, and understand signal transduction mechanisms.
• High-Throughput Screening (HTS): Utilized in drug discovery platforms to identify and optimize lead compounds with similar mechanisms of action.
• Academic & Institutional Research: Supports fundamental research in cell biology, molecular pharmacology, and medicinal chemistry at universities and research institutes.
• API Development: Investigated for use in the development of Active Pharmaceutical Ingredients (APIs) for targeted therapies under clinical evaluation.

Basic Information

Product Name	Belizatinib
CAS No.	1357920-84-3
Molecular Formula	C₂₉H₃₀N₈O₂
Molecular Weight	522.61 g/mol
Synonyms	TSR-011; TSR011; TSR 011; N-[3-[(5-Chloro-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl)amino]phenyl]acrylamide; UNII-7J8Q8X6B4P; 7J8Q8X6B4P; Belizatinib (TSR-011); N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide
EINECS	Contact for details

Quality Control

Our Belizatinib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.