Description

3-Bromo-4-Cyclopropylpyridine is a high-value, multi-functional heterocyclic building block characterized by its bromine and cyclopropyl substituents on the pyridine ring. This compound matters for its versatility in facilitating complex molecular construction, particularly in the synthesis of advanced pharmaceutical intermediates and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific steric and electronic properties into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyclopropylpyridine moiety imparts specific biological activity.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Functional Group Transformation: Used as a starting point for further functionalization, including lithiation, metal-halogen exchange, and nucleophilic aromatic substitution.

Basic Information

Item	Details
Product Name	3-Bromo-4-Cyclopropylpyridine
CAS No.	1357094-98-4
Molecular Formula	C8H8BrN
Molecular Weight	198.06 g/mol
Synonyms	4-Cyclopropyl-3-bromopyridine; 3-Bromo-4-cyclopropyl-pyridine; 3-Bromo-4-(cyclopropyl)pyridine; Pyridine, 3-bromo-4-cyclopropyl-; 1357094-98-4; 3-Br-4-CPP; 3-Bromo-4-cyclopropylpyridine (CAS 1357094-98-4)
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Cyclopropylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a light-proof secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.