Description

2-Chloro-5-Fluoro-4-(Trifluoromethyl)Pyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group, provides exceptional reactivity and stability for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The chlorine and fluorine atoms provide selective sites for nucleophilic displacement, enabling diverse functionalization.
• Fluorinated Building Block: A valuable source of fluorine atoms for introducing fluorinated motifs into target molecules to modulate lipophilicity, metabolic stability, and bioavailability.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-(Trifluoromethyl)Pyridine
CAS No.	1356113-40-0
Molecular Formula	C6H2ClF4N
Molecular Weight	199.53 g/mol
Synonyms	2-Chloro-5-fluoro-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-4-trifluoromethylpyridine; 1356113-40-0; Pyridine, 2-chloro-5-fluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.