Description

Panulisib (CAS NO 1356033-60-7) is a potent and selective small molecule inhibitor targeting the PI3K/AKT/mTOR signaling pathway, a critical regulator of cell growth and survival. This compound is of significant value in oncology research for its potential to inhibit tumor proliferation and overcome therapeutic resistance. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in the development of novel cancer therapeutics and the study of cellular signaling mechanisms.

Application

• Oncology Research & Drug Discovery: A key tool compound for investigating the role of PI3K inhibition in various cancer cell lines and animal models.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new PI3K pathway inhibitors.
• Mechanistic Studies: Essential for studying downstream effects of PI3K/AKT/mTOR pathway blockade on apoptosis, autophagy, and cell cycle progression.
• Combination Therapy Research: Investigated in preclinical studies for potential synergistic effects when used alongside chemotherapy, radiotherapy, or other targeted agents.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in signal transduction and cancer biology.
• Biomarker Identification: Aids in research aimed at discovering predictive biomarkers for patient response to PI3K-targeted therapies.

Basic Information

Product Name	Panulisib
CAS No.	1356033-60-7
Molecular Formula	C₂₄H₂₃N₇O₂
Molecular Weight	441.49 g/mol
Synonyms	PQR309; PQR 309; Bimiralisib; PI3K/mTOR Inhibitor PQR309; 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, 2-amino-N-[7-methoxy-8-[3-(4-morpholinyl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-
EINECS	Contact for details

Quality Control

Our Panulisib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.