Description

1H-Pyrrolo[3,2-B]Pyridin-6-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1354940-93-4. This heterocyclic amine derivative is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is essential for research and development chemists and manufacturers in the pharmaceutical and biotechnology sectors seeking to develop novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex heterocyclic scaffolds in drug discovery programs.
• Research & Development: Serves as a crucial reagent in academic and industrial R&D for exploring new chemical entities and biological pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the final stages or penultimate steps of API synthesis for clinical trial materials and commercial production.
• Bioconjugation & Probe Development: The amine functionality allows for conjugation, useful in creating diagnostic probes or antibody-drug conjugates (ADCs).

Basic Information

Product Name	1H-Pyrrolo[3,2-B]Pyridin-6-Amine Hydrochloride
CAS No.	1354940-93-4
Molecular Formula	C7H8ClN3
Molecular Weight	169.61 g/mol
Synonyms	6-Amino-1H-pyrrolo[3,2-b]pyridine hydrochloride; 1H-Pyrrolo[3,2-b]pyridin-6-amine, hydrochloride; 6-Amino-7-azaindole hydrochloride; 6-Amino-1H-pyrrolo[3,2-b]pyridine HCl; 1H-Pyrrolo[3,2-b]pyridin-6-amine HCl; 1354940-93-4; 6-Amino-1H-pyrrolo[3,2-b]pyridine monohydrochloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[3,2-B]Pyridin-6-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.