Description

1-Boc-4-(5-Bromo-3-Fluoro-2-Pyridyl)-3-Methylpiperazine is a high-purity, advanced pharmaceutical intermediate featuring a substituted pyridyl-piperazine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Kinase Inhibitor Development: The bromo-fluoro-pyridyl moiety makes it a valuable precursor for creating targeted kinase inhibitors.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for clients.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening.
• Process Chemistry: Used in route scouting and scale-up studies for the development of efficient manufacturing processes.

Basic Information

Product Name	1-Boc-4-(5-Bromo-3-Fluoro-2-Pyridyl)-3-Methylpiperazine
CAS No.	1354940-67-2
Molecular Formula	C16H21BrFN3O2
Molecular Weight	386.26 g/mol
Synonyms	1-Boc-4-(5-bromo-3-fluoropyridin-2-yl)-3-methylpiperazine; tert-Butyl 4-(5-bromo-3-fluoro-2-pyridinyl)-3-methyl-1-piperazinecarboxylate; 3-Methyl-1-piperazinecarboxylic acid, 4-(5-bromo-3-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester; 1-Boc-3-methyl-4-(5-bromo-3-fluoro-2-pyridyl)piperazine; 1354940-67-2; 4-(5-Bromo-3-fluoro-2-pyridinyl)-3-methyl-1-piperazinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(5-Bromo-3-Fluoro-2-Pyridyl)-3-Methylpiperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.