Description

2-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Acetonitrile is a high-value, multi-functional chemical building block that combines a pyridine ether linkage with a protected boronic ester and a nitrile group. This unique structure makes it a critical intermediate for advanced organic synthesis, particularly in the development of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds, a fundamental step in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: The pyridine and nitrile functionalities make it a precursor for creating novel ligands and organocatalysts.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for creating labeled compounds and probes for studying biological systems.

Basic Information

Product Name	2-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Acetonitrile
CAS No.	1354910-97-6
Molecular Formula	C15H21BN2O3
Molecular Weight	288.15 g/mol
Synonyms	2-((4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)acetonitrile; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-((cyanomethoxy)pyridine; 2-[(4-Methyl-5-{4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl}pyridin-2-yl)oxy]acetonitrile; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-cyanoethoxy)pyridine (isomer check); 2-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yloxy)acetonitrile; Boronic ester pyridine nitrile derivative; Pyridine boronic ester pinacol cyanoethyl ether.
EINECS	Contact for details

Quality Control

Our 2-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a controlled, low-humidity environment to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.