Description

n-(3-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propyl)Acetamide is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which are fundamental to modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those targeting protein kinases and other enzyme inhibitors.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety makes it an essential reagent for constructing biaryl and heterobiaryl structures common in modern pharmaceuticals.
• Medicinal Chemistry & Drug Discovery: Used extensively in research labs for structure-activity relationship (SAR) studies and lead optimization processes.
• Pre-clinical & Clinical Trial Material Synthesis: Employed in the scale-up synthesis of compounds for pre-clinical evaluation and clinical trial material (CTM) manufacturing.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Potential application in the development of new active ingredients with complex heterocyclic structures.

Basic Information

Product Name	n-(3-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propyl)Acetamide
CAS No.	1354724-87-0
Molecular Formula	C19H32BN3O3
Molecular Weight	361.29 g/mol
Synonyms	N-[3-[[3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]propyl]acetamide; 2-Pyridinamine, N-[3-(acetylamino)propyl]-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1354724-87-0; 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(3-(acetamido)propyl)pyridin-2-amine; Acetamide, N-[3-[[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]propyl]-; Boronic acid, B-[2-[[3-(acetylamino)propyl]amino]-5-methyl-3-pyridinyl]-, 1,3-propanediol cyclic ester
EINECS	Contact for details

Quality Control

Our n-(3-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise the integrity of the boronic ester group. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.