Description

4-(2-Chloro-Pyridine-3-Carbonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is essential for research institutions, CROs, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially for neurological and cancer treatments.
• API Synthesis: Used as a key chiral building block for constructing the piperazine core in various Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Supports route scouting and process development from laboratory to pilot and commercial scale manufacturing.
• Custom Synthesis: Serves as a starting material for the custom synthesis of specialized analogs and derivatives for proprietary research.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	4-(2-Chloro-Pyridine-3-Carbonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353980-43-4
Molecular Formula	C16H20ClN3O3
Molecular Weight	337.80 g/mol
Synonyms	tert-Butyl 4-[(2-chloropyridine-3-yl)carbonyl]-3-methylpiperazine-1-carboxylate; 1-Boc-4-(2-chloronicotinoyl)-3-methylpiperazine; 3-Methyl-1-(tert-butoxycarbonyl)-4-(2-chloronicotinoyl)piperazine; 4-(2-Chloronicotinoyl)-3-methyl-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-methyl-4-(2-chloronicotinoyl)piperazine; 4-(2-Chloropyridine-3-carbonyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester; 1353980-43-4
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Pyridine-3-Carbonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.