Description

[1-(2-Chloro-Pyridine-3-Carbonyl)-Piperidin-2-Ylmethyl]-Carbamic Acid tert-Butyl Ester CAS NO 1353980-08-1 is a sophisticated heterocyclic building block and advanced pharmaceutical intermediate. This compound is of critical importance for medicinal chemistry research and the development of new active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and other enzyme-targeted therapies. It is primarily needed by pharmaceutical R&D laboratories, custom synthesis houses, and manufacturers of high-potency active pharmaceutical ingredients (HPAPIs) seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting proteases and other enzymatic pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Custom Synthesis: Serves as a critical starting material or intermediate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• API Development: Integral to the process development and scale-up synthesis of potential new active pharmaceutical ingredients, especially in the pre-clinical and clinical trial material stages.
• Biochemical Tool Compound: Can be utilized in biochemical assays to study enzyme inhibition and understand biological mechanisms of action.
• Library Synthesis: Employed in the generation of focused chemical libraries for high-throughput screening (HTS) against novel biological targets.

Basic Information

Product Name	[1-(2-Chloro-Pyridine-3-Carbonyl)-Piperidin-2-Ylmethyl]-Carbamic Acid tert-Butyl Ester
CAS No.	1353980-08-1
Molecular Formula	C17H22ClN3O3
Molecular Weight	351.83 g/mol
Synonyms	tert-Butyl N-[[1-[(2-chloropyridine-3-carbonyl)piperidin-2-yl]methyl]carbamate; 1-[(2-Chloropyridine-3-carbonyl)piperidin-2-yl]methyl-carbamic Acid tert-Butyl Ester; 2-Chloro-N-[2-[[(tert-butoxy)carbonylamino]methyl]piperidin-1-yl]pyridine-3-carboxamide; BOC-Protected 1-(2-Chloronicotinoyl)-2-(aminomethyl)piperidine; (2-Chloronicotinoyl)piperidine BOC-Protected Amine Intermediate
EINECS	Contact for details

Quality Control

Our [1-(2-Chloro-Pyridine-3-Carbonyl)-Piperidin-2-Ylmethyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We can support development projects with material produced under GMP-like conditions for non-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.