Description

4-{[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Methyl}-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and pyridine-based molecular architecture. This compound matters for its critical role as a versatile building block in the synthesis of complex, biologically active molecules, offering precise chemical functionality for downstream modifications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the bespoke synthesis of complex molecules for client projects.
• Chemical Biology Probes: Can be utilized in the synthesis of chemical probes for studying enzyme function or protein-ligand interactions.

Basic Information

Product Name	4-{[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Methyl}-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353979-99-3
Molecular Formula	C18H24ClN3O3
Molecular Weight	365.86 g/mol
Synonyms	4-[[(2-Chloropyridine-3-carbonyl)amino]methyl]piperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-[[(2-chloro-3-pyridinyl)carbonyl]amino]methyl]piperidine; tert-Butyl 4-(((2-chloronicotinamido)methyl)piperidine-1-carboxylate; 4-(Aminomethyl)-1-N-Boc-piperidine-2-chloronicotinamide; N-[(1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl]-2-chloronicotinamide; 2-Chloro-N-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)nicotinamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. For GMP-grade material or material meeting specific pharmacopeial standards (e.g., USP/EP), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.