Description

4-Bromo-5-Methylpicolinonitrile is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromo and nitrile functionalities into pyridine-based scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its halogenated pyridine core.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands used in catalysis and material science.
• Functional Material Development: Incorporated into the design of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized to build molecular probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	4-Bromo-5-Methylpicolinonitrile
CAS No.	1353856-72-0
Molecular Formula	C7H5BrN2
Molecular Weight	197.04 g/mol
Synonyms	4-Bromo-5-methylpyridine-2-carbonitrile; 5-Methyl-4-bromopicolinonitrile; 2-Cyano-4-bromo-5-methylpyridine; 4-Bromo-5-methyl-2-pyridinecarbonitrile; 4-Bromo-5-methyl-2-cyanopyridine; 2-Pyridinecarbonitrile, 4-bromo-5-methyl-
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Methylpicolinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our commitment to quality assurance ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.