Description

N,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester and a trifluoroethylamine moiety. This compound is a critical building block for medicinal chemists, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex molecules. It is primarily used in the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach aryl or heteroaryl groups to the pyridine core.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Pre-clinical Drug Development: Serves as a building block for producing compounds for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with enhanced properties.

Basic Information

Product Name	N,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine
CAS No.	1353746-93-6
Molecular Formula	C15H22BF3N2O2
Molecular Weight	330.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,4-dimethyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine; 2-Pyridinamine, N,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)-; N-Methyl-N-(2,2,2-trifluoroethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 1353746-93-6; Boronic acid, B-[6-[methyl(2,2,2-trifluoroethyl)amino]-4-methyl-2-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our N,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.