Description

4-Methyl-n-(1-Methylpiperidin-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester group and a piperidine-substituted pyridin-2-amine scaffold. This compound is critical for modern drug discovery, primarily serving as a key building block in the synthesis of targeted small molecule therapeutics through cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors who are developing novel kinase inhibitors, central nervous system (CNS) agents, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester functionality enables efficient carbon-carbon bond formation, a cornerstone of modern medicinal chemistry.
• Kinase Inhibitor Development: Used in the research and production of potential drug candidates targeting various kinase enzymes involved in cancer and inflammatory diseases.
• CNS Drug Discovery: The structural motif is relevant for creating compounds that may cross the blood-brain barrier for neurological and psychiatric applications.
• Chemical Biology & Proteomics: Employed as a molecular tool or tag in the study of protein function and interaction.
• Library Synthesis for High-Throughput Screening: Used to generate diverse compound libraries to identify new lead molecules.
• Agrochemical Research: Potential intermediate in the development of new, more effective crop protection agents.
• Material Science Research: Investigated for incorporation into novel organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Methyl-n-(1-Methylpiperidin-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1353718-70-3
Molecular Formula	C18H30BN3O2
Molecular Weight	331.27 g/mol
Synonyms	4-Methyl-N-(1-methyl-4-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine; 2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(1-methylpiperidin-4-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N-(1-methylpiperidin-4-yl)pyridin-2-amine; 1353718-70-3; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(1-methylpiperidin-4-yl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our 4-Methyl-n-(1-Methylpiperidin-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.