Description

3-Fluoro-5-(Trifluoromethoxy)Benzoyl Chloride, 97% is a high-purity, multi-functional aromatic acid chloride building block. This compound is essential for introducing the 3-fluoro-5-(trifluoromethoxy)benzoyl moiety into target molecules, a key step in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the lipophilicity and metabolic stability imparted by the fluorine and trifluoromethoxy groups.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the unique fluorinated aromatic core enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Production: Serves as a key building block for fluorinated aromatic components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to functionalize polymers, creating specialty polyamides, polyesters, or coatings with enhanced chemical resistance and specific surface properties.
• Peptide & Protein Research: Acts as an acylating agent for modifying amino groups in peptides or biomolecules for biochemical studies and probe development.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom chemical synthesis services and scale-up production for client-specific molecules.

Basic Information

Item	Details
Product Name	3-Fluoro-5-(Trifluoromethoxy)Benzoyl Chloride, 97%
CAS No.	1352999-78-0
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	3-Fluoro-5-(trifluoromethoxy)benzoyl chloride; 3-Fluoro-5-(trifluoromethoxy)benzoic acid chloride; 3-Fluoro-α,α,α-trifluoro-5-methoxybenzoyl chloride; 5-(Trifluoromethoxy)-3-fluorobenzoyl chloride; Benzoyl chloride, 3-fluoro-5-(trifluoromethoxy)-; 3-Fluoro-5-trifluoromethoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethoxy)Benzoyl Chloride, 97% is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency meet the specified standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and alcohols; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain purity and prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.