Description

5-Bromo-3-Iodopyrazolo[1,5-A]Pyridine is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which provides two distinct halogen handles (bromine and iodine) for selective cross-coupling reactions, enabling the rapid construction of complex pharmaceutical and agrochemical intermediates. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules. Its specific reactivity profile makes it a critical reagent for structure-activity relationship (SAR) studies and lead optimization programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used to build complex heterocyclic cores found in modern herbicides, fungicides, and insecticides.
• Material Science: Serves as a building block for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Cross-Coupling Reactions: The iodine and bromine substituents allow for sequential, site-selective Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed couplings.
• Chemical Biology: Utilized as a probe or linker in the development of chemical tools and bioconjugates.
• Academic & Contract Research: Essential for methodological development and exploring new reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-3-Iodopyrazolo[1,5-A]Pyridine
CAS No.	1352881-82-3
Molecular Formula	C7H4BrIN2
Molecular Weight	322.93 g/mol
Synonyms	5-Bromo-3-iodopyrazolo[1,5-a]pyridine; Pyrazolo[1,5-a]pyridine, 5-bromo-3-iodo-; 3-Iodo-5-bromopyrazolo[1,5-a]pyridine; 5-Bromo-3-iodo-1H-pyrazolo[1,5-a]pyridine; 5-Bromo-3-iodo-pyrazolo[1,5-a]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodopyrazolo[1,5-A]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.