Description

Azd6738 CAS NO 1352226-88-0 is a potent and selective small molecule inhibitor of the Ataxia Telangiectasia and Rad3-related (ATR) kinase, a critical component of the DNA damage response (DDR) pathway. This compound is of significant interest for its potential to sensitize cancer cells to DNA-damaging agents and replication stress, offering a promising strategy for oncology research and therapeutic development. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in preclinical studies focused on cancer biology, combination therapies, and the development of novel targeted treatments.

Application

• Oncology Research: Used as a key pharmacological tool to study the ATR signaling pathway and its role in DNA repair mechanisms.
• Drug Discovery & Development: Serves as a reference compound or a lead molecule in the design and optimization of novel ATR inhibitors.
• Combination Therapy Studies: Investigated in preclinical models to enhance the efficacy of chemotherapy, radiotherapy, and PARP inhibitors by inhibiting DDR.
• Biochemical Assays: Employed in high-throughput screening and in vitro kinase assays to evaluate ATR inhibition and selectivity.
• Cell Biology Studies: Used to induce replication stress and study cell cycle checkpoints, genomic instability, and apoptosis in cancer cell lines.
• Synthsis Intermediate: Acts as a critical building block or intermediate in the custom synthesis of related analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Azd6738
CAS No.	1352226-88-0
Molecular Formula	C₂₀H₂₃N₇O₂
Molecular Weight	393.45 g/mol
Synonyms	AZD-6738; AZD 6738; ATR Inhibitor AZD6738; 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole; Ceralasertib; 1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-
EINECS	Contact for details

Quality Control

Our Azd6738 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and MS for structural confirmation, to ensure identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term storage, keep at 2-8°C. The compound is hygroscopic and should be handled in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.