Description

n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Cyclopropanesulfonamide is a high-value, organoboron-containing building block critical for modern pharmaceutical and agrochemical research. This compound matters because its unique structure, featuring a protected boronic ester and a cyclopropanesulfonamide moiety, enables key cross-coupling reactions and serves as a versatile intermediate in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, particularly in kinase inhibitor programs and other small-molecule therapeutics.
• Agrochemical Synthesis: Intermediate for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein function.
• Advanced Material Synthesis: Building block for organic electronic materials and polymers requiring specific boron-functionalized units.

Basic Information

Product Name	n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Cyclopropanesulfonamide
CAS No.	1351381-28-6
Molecular Formula	C16H23BN2O4S
Molecular Weight	350.24 g/mol
Synonyms	2-Cyclopropylsulfonamido-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]cyclopropanesulfonamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-amine, N-cyclopropylsulfonyl derivative; Cyclopropanesulfonamide, N-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; CAS 1351381-28-6; Pinacol ester of [2-(Cyclopropylsulfonylamino)-4-methylpyridin-5-yl]boronic acid
EINECS	Contact for details

Quality Control

Our n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Cyclopropanesulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.