Description

Loxo-195 CAS NO 1350884-56-8 is a potent and selective small molecule inhibitor designed for targeted cancer therapy research. This compound is of significant interest for its role in studying resistance mechanisms and developing next-generation oncology treatments. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on precision medicine and kinase inhibitor development.

Application

• Oncology Research & Drug Discovery: A key tool compound for investigating resistance pathways in cancers treated with TRK inhibitors.
• Biochemical Assay Development: Used in high-throughput screening and enzymatic assays to study kinase inhibition profiles.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy of overcoming drug resistance.
• Mechanism of Action (MoA) Studies: Essential for understanding the structural biology and binding kinetics of targeted therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Combinatorial Therapy Research: Explored in studies evaluating synergistic effects with other therapeutic agents.

Basic Information

Product Name	Loxo-195
CAS No.	1350884-56-8
Molecular Formula	C31H34F2N6O3
Molecular Weight	576.64 g/mol
Synonyms	LOXO-195; (S)-N-(5-((R)-2-(2,5-Difluorophenyl)-1-methylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide; LOXO 195; UNII-1J8H6U3P8F; 1J8H6U3P8F; BDBM50164957; HY-101877; Altiratinib analog
EINECS	Contact for details

Quality Control

Every batch of Loxo-195 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support your research, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.