Description

(5-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride is a high-purity, organofluorine building block and pharmaceutical intermediate of significant commercial interest. Its core value lies in the trifluoromethylpyridine scaffold, which is prized for enhancing the metabolic stability, lipophilicity, and bioavailability of active compounds. This material is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors engaged in the development of novel small-molecule therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Incorporated into the design of advanced polymers, liquid crystals, and electronic materials to modify thermal and electronic properties.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and molecular tags to study biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Item	Detail
Product Name	(5-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride
CAS No.	1350637-24-9
Molecular Formula	C7H8Cl2F3N2
Molecular Weight	251.05 g/mol
Synonyms	2-(Aminomethyl)-5-(trifluoromethyl)pyridine dihydrochloride; (5-Trifluoromethyl-2-pyridinyl)methanamine dihydrochloride; 2-(Aminomethyl)-5-(trifluoromethyl)pyridine hydrochloride (1:2); 5-(Trifluoromethyl)picolylamine dihydrochloride; α-Picolylamine, 5-trifluoromethyl-, dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of (5-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure it meets the exacting standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.