Description

Lefamulin Acetate is the acetate salt form of a novel pleuromutilin antibiotic, specifically developed for systemic use. This compound is critical for pharmaceutical research and development targeting multidrug-resistant bacterial infections. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions in the development of next-generation antibacterial therapeutics.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of systemic antibacterial drugs.
• Reference Standard in analytical laboratories for quality control and method development.
• Biochemical Research for studying bacterial protein synthesis and mechanisms of antibiotic resistance.
• Preclinical and Clinical Development of novel antibiotic treatments, particularly for community-acquired bacterial pneumonia (CABP).
• Process Chemistry and scale-up synthesis for commercial pharmaceutical production.

Basic Information

Product Name	Lefamulin Acetate
CAS No.	1350636-82-6
Molecular Formula	C32H49NO8S • C2H4O2
Molecular Weight	659.8 g/mol (for the acetate salt)
Synonyms	BC-3781 Acetate; (1S,2S,4S)-4-[(2S)-2-Amino-3,3-dimethylbutanoyl]-2-[(1R,2S,3S,4R)-3-[(2S)-2-[(1S)-1-hydroxyethyl]-1-methyl-4-oxo-4-[(phosphonooxy)methyl]azetidin-1-yl]-2-hydroxy-1-methyl-4-[(E)-2-(methylamino)ethenyl]cyclohexyl]-2-hydroxy-N,N,1-trimethyl-4-oxo-3-(sulfomethyl)-6,9-dioxa-3λ6-thia-1-azabicyclo[4.3.0]nona-7,10-diene-8-carboxamide acetate; Pleuromutilin derivative BC-3781 acetate; NVP-BC3781 acetate
EINECS	Contact for details

Quality Control

Our Lefamulin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.