Description

Taccalonolide Aj CAS NO 1349904-82-0 is a highly potent microtubule-stabilizing agent, a member of the taccalonolide class of natural products isolated from plants of the *Tacca* genus. This compound is of significant interest due to its unique mechanism of action, which overcomes certain forms of taxane resistance, making it a valuable tool for oncology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics and studying cytoskeletal dynamics.

Application

• Anticancer Drug Discovery & Development: Serves as a lead compound or a pharmacological probe for developing novel chemotherapeutic agents targeting microtubules.
• Mechanistic Biological Research: Used in cell biology and biochemistry studies to investigate microtubule stabilization, mitotic arrest, and apoptosis pathways.
• Overcoming Drug Resistance: Employed in research focused on bypassing P-glycoprotein-mediated multidrug resistance, a common challenge with taxane-based therapies.
• Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for medicinal chemistry programs aimed at synthesizing analogs with improved potency or pharmacokinetic profiles.
• In Vitro & In Vivo Preclinical Studies: Utilized in cell-based assays and animal models to evaluate antitumor efficacy and toxicology.
• Pharmaceutical Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Taccalonolide Aj
CAS No.	1349904-82-0
Molecular Formula	C34H46O11
Molecular Weight	630.73 g/mol
Synonyms	Taccalonolide AJ; (1S,2R,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-(Acetyloxy)-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-1H-picene-4a-carboxylic acid methyl ester; Taccalonolide A J
EINECS	Contact for details

Quality Control

Our Taccalonolide Aj is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.