Description

(S)-1-[(Pyridin-4-Yl)Carbonyl]Pyrrolidin-3-Amine Dihydrochloride is a high-purity chiral amine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold essential for developing novel active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a precursor in multi-step synthetic routes to final APIs, leveraging its pyrrolidine and pyridine motifs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Asymmetric Synthesis Catalyst Ligand: Potential use as a precursor for chiral ligands or organocatalysts in enantioselective transformations.
• Bioconjugation & Probe Development: The amine functionality allows for conjugation to fluorescent tags or other reporter molecules for biochemical assays.

Basic Information

Product Name	(S)-1-[(Pyridin-4-Yl)Carbonyl]Pyrrolidin-3-Amine Dihydrochloride
CAS No.	1349700-01-1
Molecular Formula	C10H14N3O • 2HCl
Molecular Weight	279.16 g/mol (for dihydrochloride salt)
Synonyms	(3S)-1-(Pyridine-4-carbonyl)pyrrolidin-3-amine dihydrochloride; (S)-3-Amino-1-(isonicotinoyl)pyrrolidine dihydrochloride; (S)-1-(Isonicotinoyl)pyrrolidin-3-amine dihydrochloride; (S)-N-(3-Aminopyrrolidin-1-yl)(pyridin-4-yl)methanone dihydrochloride; (S)-1-(4-Pyridinylcarbonyl)-3-pyrrolidinamine dihydrochloride; Pyrrolidin-3-amine, 1-(4-pyridinylcarbonyl)-, (3S)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-[(Pyridin-4-Yl)Carbonyl]Pyrrolidin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.