Description

Axitinib Sulfonyl is a high-purity pharmaceutical intermediate and reference standard of significant importance in modern drug development and research. Its primary value lies in its role as a key building block for the synthesis of Axitinib, a potent and selective tyrosine kinase inhibitor used in targeted cancer therapy. This compound is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in the development, quality control, and production of innovative oncology treatments. We supply Axitinib Sulfonyl CAS NO 1348536-59-3 to the global market with a commitment to consistent quality and reliable supply chain integrity.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of the active pharmaceutical ingredient (API) Axitinib.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) testing of Axitinib API and related substances.
• Research & Development: Serves as a key starting material (KSM) or building block in medicinal chemistry programs for developing new kinase inhibitor analogs.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing process of Axitinib.
• Impurity Standard: Employed to identify, quantify, and control potential sulfonyl-related impurities in Axitinib drug substances and products.

Basic Information

Product Name	Axitinib Sulfonyl
CAS No.	1348536-59-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Axitinib Sulfone; Axitinib Sulfone Impurity; Axitinib Sulfoxide; N-Methyl-2-[[3-((E)-2-pyridin-2-ylethenyl)-1H-indazol-6-yl]sulfanyl]benzamide Sulfone; AG-013736 Sulfone; Axitinib Related Compound Sulfone; Axitinib Sulfonyl Derivative
EINECS	Contact for details

Quality Control

Our Axitinib Sulfonyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.