Description

2-Cyclopropoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, advanced pharmaceutical intermediate and building block featuring a pyridine core functionalized with both a cyclopropoxy group and a pinacol boronate ester. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and fungicides that require complex pyridine-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Essential reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl systems.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes.
• Academic & Industrial R&D: A versatile tool for synthetic organic chemists in both university laboratories and corporate R&D centers exploring new chemical spaces.

Basic Information

Product Name	2-Cyclopropoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1346707-95-6
Molecular Formula	C17H24BNO3
Molecular Weight	301.19 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropoxypyridine; 2-Cyclopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(2-Cyclopropoxypyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(2-Cyclopropoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pyridine, 2-cyclopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1346707-95-6
EINECS	Contact for details

Quality Control

Our production of 2-Cyclopropoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive coupling reactions. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.