Description

Hydroxy Adapalene is a high-purity synthetic retinoid derivative, representing a key advanced intermediate in modern pharmaceutical synthesis. Its primary commercial value lies in its critical role as a precursor for the development of next-generation topical dermatological treatments, particularly for acne and psoriasis. This compound is essential for R&D laboratories and manufacturers in the global pharmaceutical and fine chemical sectors seeking to innovate in dermatology and retinoid-based therapies.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of novel topical retinoid drugs and their analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structure for research into new chemical entities targeting retinoid receptors.
• Dermatological R&D: Critical for academic and industrial research focused on acne vulgaris, psoriasis, and photoaging treatments.
• Fine Chemical Synthesis: Used in custom synthesis and process development for high-value, complex organic molecules.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Hydroxy Adapalene
CAS No.	1346599-76-5
Molecular Formula	C28H28O4
Molecular Weight	428.52 g/mol
Synonyms	6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid; Hydroxy Adapalene Impurity; Adapalene Hydroxy Impurity; Adapalene Related Compound; CD 271 Related Substance; 6-[3-(Adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Hydroxy Adapalene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.