Description

6-((Trimethylsilyl)Ethynyl)-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine is a high-value, organosilicon-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical research and material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate unique silyl-protected alkyne and fused pyranopyridine motifs into their target structures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the pyranopyridine scaffold can impart specific biological activity.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors.
• Chemical Biology Probe Synthesis: Employed to create labeled compounds or molecular probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne group is a versatile handle for Sonogashira and other palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Utilized in the synthesis of novel nitrogen-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	6-((Trimethylsilyl)Ethynyl)-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine
CAS No.	1346446-98-7
Molecular Formula	C13H19NOSi
Molecular Weight	233.38 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine; 3,4-Dihydro-2H-pyrano[2,3-b]pyridine, 6-[(trimethylsilyl)ethynyl]-; 6-(Trimethylsilylethynyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine; 6-(Trimethylsilylethynyl)dihydropyranopyridine; TMS-Ethynyl Dihydropyranopyridine; CAS 1346446-98-7
EINECS	Contact for details

Quality Control

Our 6-((Trimethylsilyl)Ethynyl)-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keep at 2-8°C under an inert atmosphere such as nitrogen or argon to maximize stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.