Description

Erdafitinib is a potent and selective small-molecule inhibitor of fibroblast growth factor receptors (FGFRs), a key target in precision oncology. This compound is crucial for pharmaceutical research and development, particularly in the creation of targeted cancer therapies. It is primarily needed by pharmaceutical companies, biotechnology research institutions, and academic laboratories engaged in oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical active pharmaceutical ingredient (API) in the formulation of targeted cancer therapeutics.
• Oncology Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting FGFR-altered tumors.
• Biochemical Assay Development: Employed in high-throughput screening and assay validation to study FGFR signaling pathways and inhibitor efficacy.
• Mechanism of Action Studies: Utilized in cellular and molecular biology research to understand tumor biology and resistance mechanisms.
• Drug Discovery & Development: A key building block for medicinal chemists in the synthesis of novel FGFR inhibitor analogs and prodrugs.

Basic Information

Product Name	Erdafitinib
CAS No.	1346242-81-6
Molecular Formula	C₂₄H₃₀ClFN₄O₃
Molecular Weight	476.97 g/mol
Synonyms	JNJ-42756493; Balversa (brand name); 1-(3,5-Dimethoxyphenyl)-3-[1-(6-methylpyridin-2-yl)ethyl]-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4(1H,3H)-dione; FGFR Inhibitor JNJ-42756493; UNII-3C7K4056YF
EINECS	Contact for details

Quality Control

Our Erdafitinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet high standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing specifications and test results, including HPLC purity, is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.