Description

Altiratinib is a potent, small-molecule inhibitor targeting multiple receptor tyrosine kinases, including MET, TIE2, and VEGFR2. This compound is of significant interest for its potential in disrupting key oncogenic signaling pathways involved in tumor growth and angiogenesis. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in preclinical oncology studies and drug discovery programs for solid tumors.

Application

• Oncology Research: A key investigational tool for studying the inhibition of MET, TIE2, and VEGFR2 signaling cascades in various cancer cell lines and animal models.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel multi-kinase inhibitors for cancer therapy.
• Biochemical Assays: Used in high-throughput screening (HTS) and enzymatic assays to evaluate kinase inhibition potency and selectivity profiles.
• Mechanistic Studies: Facilitates research into tumor microenvironment interactions, particularly focusing on angiogenesis and metastasis.
• Preclinical Formulation Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to assess drug-like properties and efficacy.

Basic Information

Product Name	Altiratinib
CAS No.	1345847-93-9
Molecular Formula	C₂₉H₂₈F₂N₈O₃
Molecular Weight	574.58 g/mol
Synonyms	Altiratinib; DCC-2701; 4-[[2-Fluoro-4-[[[(3S)-3-fluoro-1-pyrrolidinyl]carbonyl]amino]phenyl]amino]-N-methyl-6-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]-1H-pyrrolo[2,3-b]pyridine-7-carboxamide; DCC2701; UNII-4J2Z8K683K
EINECS	Contact for details

Quality Control

Our Altiratinib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by comprehensive analytical documentation, including HPLC chromatograms and mass spectrometry data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.