Description

N3-Peg8-Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide (N3) group and a carboxylic acid (COOH) terminal, separated by an 8-unit PEG spacer. This compound matters for its crucial role in facilitating bioconjugation and click chemistry reactions, enabling the precise and efficient coupling of biomolecules, polymers, and surfaces. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug delivery system development, diagnostic probe synthesis, and surface functionalization.

Application

• Bioconjugation reagent for linking azide-modified biomolecules (e.g., antibodies, peptides) to carboxyl-reactive surfaces or other molecules.
• Key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Surface modification and functionalization of nanoparticles, quantum dots, and other nanomaterials for biomedical applications.
• Development of hydrogels and biocompatible polymer networks with tailored chemical properties.
• Synthesis of diagnostic probes and imaging agents for in vitro and in vivo applications.
• Facilitating click chemistry (CuAAC or strain-promoted) workflows in chemical biology and materials science research.
• Preparation of PEGylated compounds to improve solubility, stability, and pharmacokinetic profiles.

Basic Information

Product Name	N3-Peg8-Ch2Cooh
CAS No.	1343472-07-0
Molecular Formula	C27H51N3O12
Molecular Weight	609.71 g/mol
Synonyms	Azido-PEG8-acetic acid; 2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; N3-PEG8-COOH; Azido-PEG8-COOH; 8-Azido-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid; Azido-octaethylene glycol-acetic acid; PEG8-Azide-Acid
EINECS	Contact for details

Quality Control

Our N3-Peg8-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure compliance with high-purity research and GMP-grade standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.